Welcome to DeSpain Cayce.

Proudly serving the Columbia, Missouri area for over 20 years.

Welcome to DeSpain Cayce.

We offer comprehensive medical and cosmetic dermatology services, directed by Dr. John DeSpain and Dr. Kimberly Cayce.

Welcome to DeSpain Cayce.

We strive to excel at providing compassionate medical, surgical, and cosmetic skin care for all patients.

DeSpain Cayce Dermatology Center and Medical Spa

The physicians of DeSpain Cayce Dermatology Center and Medical Spa have been proudly serving the Columbia, Missouri area for over 20 years. Our professional staff is dedicated to fulfilling all your dermatological and medical spa wants and needs with tailored services for every client. We offer comprehensive medical and cosmetic dermatology services, directed by Dr. John DeSpain and Dr. Kimberly Cayce.

Our Blog

  • MEDICAL DERMATOLOGY

    A dermatologist has the unique ability to care for all medical and surgical skin problems. We specialize in the diagnosis and treatment of all conditions of the skin, hair and nails. Dr. John DeSpain and Dr. Kimberly Cayce are board-certified dermatologists with years of experience in treating a full range of skin conditions. Our professional
  • TESTIMONIALS

    Check out what DeSpain Cayce Medical Spa patients have to say! *You can also scroll to the bottom of the page to leave your own feedback for us “I have been a patient of John DeSpain’s since moving to Columbia 14 years ago. Dr. DeSpain, Dr. Cayce and their staff have treated our family for many things over
  • THE PRACTICE

    Medical Spa Monday7:30 am - 5:00 pm Tuesday7:30 am - 5:00 pm Wednesday7:30 am - 5:00 pm Thursday7:30 am - 5:00 pm Friday7:30 am - 4:30 pm Select Saturdays9:00 am - 4:00 pm Get In Touch! DeSpain CayceThe DeSpain Cayce Dermatology team strives to excel at providing compassionate medical, surgical, and cosmetic skin care for
  • REFERRALS

    We make every effort to accommodate each physician referral to the best of our ability. Physicians referrals are seen Monday through Thursday and we accept almost every insurance plan. Dr. DeSpain and Dr. Cayce make it their goal to communicate appropriately with all referring physicians through fax and phone calls. We believe that this provides

    Medical Spa Services

  • “Lunchtime” Treatments

    We offer several treatments than can be done in 30 minutes or less (over a lunch break) that will not interfere with your “To-do List”! Read More…

  • Facials

    No matter what your skin type, we have a facial for you. Read More…

  • Skin Tightening

    After just one treatment, your skin will gradually reflect a more refreshed, uplifted appearance. Read More…

  • Body Sculpting

    Now you can attack these problem areas with the non-invasive CoolSculpting procedure. Read More…

  • Smooth Wrinkles

    Botox cosmetic reduces the appearance of unwanted facial lines and wrinkles and takes just a few minutes. Read More…

  • Restore Lost Volume

    A skillfully injected filler in the mid face can ‘re inflate’ or naturally restore mid and upper facial volume and turn back time 5-15 years. Read More…

  • Treat Acne Scarring

    We offer treatments for all types of acne scarring, usually utilizing a combination of procedures. Read More…

  • Tattoo Removal

    Laser tattoo removal treatments offer a safe and effective way to remove a tattoo that no longer meets your needs. Read More…

  • Laser Hair Removal

    Laser Hair Removal requires several sessions to achieve long-term hair reduction. Read More…

  • Vein Treatment

    For spider and small varicose veins. Read More…

  • Skin Resurfacing

    Noticeable results are often realized in just a few treatments. Read More…

  • Spot Treatment

    Pigment problems as well as textural issues can be addressed in a number of ways. Read More…