Fillers are FDA approved synthetic materials that we use to treat wrinkles, lines and unwanted folds in facial skin. Tremendous advances have been made in this area. Compared to injecting collagen in the 1990′s, we now have safer, longer-lasting products and improved injection techniques. Some products even stimulate your own body’s collagen resulting in even longer improvements. Fillers are often used in combination with other cosmetic skin treatments.

We used to concentrate on filling lines with these products, like spackling cracks in drywall, but the newest methods focus on restoring volume. We still inject to correct fine lines and subtle areas, but we know now that volume loss from the mid cheeks causes us to lose our youthful appearances. As the face ages we lose soft tissue (and even bone) particularly in the mid-face, resulting in overlying lax skin. A skillfully injected filler in the mid face can ‘re inflate’ or naturally restore mid and upper facial volume and turn back time 5-15 years.

In our office, Dr. Cayce and Dr. Despain use three types of fillers, and customize every treatment to particular patient wants and needs. These include poly-L-lactic acid (Sculptra®), and hyaluronic acid (HA, brand names: Juvederm®). Many times we use a combination of products during a session or over time in a given patient. A typical appointment is about an hour long, as it includes patient consent and instruction, photographs, topical numbing, the injection itself, and post-care. Patients normally are able to return to work or home in good sorts and able to wear makeup over the areas treated immediately, and after ‘taking it easy’ for the rest of the day able to go about their normal activities.

We are highlighting the newest arrow in our quivers, Voluma XC®, a special type of Juvederm® specifically designed to restore volume by injection into the mid face. Like other HA fillers, it contains a modified HA, derived from a naturally occurring complex sugar. Voluma XC® is uniquely manufactured to provide support for the deeper layers of the skin, which provides a subtle lift of the mid and lower face. Results are expected to last for up to two years.

Schedule an in-office consultation with our esthetics team and we will customize a treatment plan specific to your needs, and determine if you are a candidate for Voluma XC® (or other treatments). Call (573) 446-5166.

Restore Lost Skin Volume | Columbia Mo | Juvederm


Whether you have “parentheses” around your mouth or wrinkles by your nose, JUVEDERM XC® is the only FDA-approved filler that can smooth out your problem areas. This nonsurgical procedure uses a fine needle to ease the natural feeling substance around the wrinkled areas. Safe and effective, this gel replenishes the volume your skin has lost, while still looking and feeling natural.

There is no downtime following this procedure, although your doctor may recommend avoiding certain activities for up to 24 hours. This HA dermal filler is long lasting, proven to last up to one year after only one treatment. It is safe and successful for all different skin types and colors. A customized treatment plan is laid out for each patient, ensuring that you get the perfect results that are tailored to your specific needs.

Juvederm® is a soft tissue filler with natural long-lasting beauty enhancement. This injection is physician administered.

Hyaluronic Acid based Juvederm® is injected into the skin in tiny amounts with a very fine needle. This

FDA-approved filler uses Hylacross technology to give Juvederm® its smooth gel consistency.

  • Smoothes wrinkles and folds with customized treatments.
  • Gives treated area more volume.
  • Instantaneous and long-lasting, natural enhancement that is gentle and safe.
  • A single treatment can be effective for 4 to 6 months or even up to a year.

Learn More at Juvederm.

Call (573) 446-5166 to set up your free consultation today!

Restore Lost Skin Volume | Columbia Mo | Voluma


JUVEDERM VOUMA XC is specifically designed to add volume to all three areas of your cheek. This injectable gel is the only filler FDA-approved to instantly add volume to the cheeks. If you are over the age of 21, JUVEDERM VOLUMA XC will work to restore that youthful look by giving your cheeks a slight lift.

Unlike other products, JUVEDERM VOLUMA XC specifically focuses on your cheeks. With optimal treatment, the effects are proven to last up to two years. Side effects can last up to seven days, but you should be able to resume your normal activities 24 hours after treatment.

Learn More at Voluma XC.

Call (573) 446-5166 to set up your free consultation today!

Restore Lost Skin Volume | Columbia Mo | Sculptra


Gradual changes for long-lasting results. These injections are all physician administered.

Sculptra Aesthetic® is not a filler but works by stimulating your own collagen creating smooth, long lasting results. As you age, your body’s collagen production decreases and you lose soft tissue as well as bone structure. This loss of deep tissue (volume loss) results in skin laxity and wrinkles or folds.

Sculptra Aesthetic® works to correct shallow to deep facial wrinkles and folds, as it replaces lost collagen, which can help provide a refined, more youthful appearance. Treatment consists of at least two scheduled sessions a month or more apart and may take as many as six or more sessions over the course of many months. Annual touch up sessions can be expected. Results are expected for at least two years.

This treatment is appropriate for patients of any age noting volume loss, usually over the age of 30.

Learn More at Sculptra Aesthetic

Call (573) 446-5166 for your complimentary esthetic consultation today!

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  • DeSpain Cayce

    The DeSpain Cayce Dermatology team strives to excel at providing compassionate medical, surgical, and cosmetic skin care for all patients.

    Dermatology Phone: (573) 234-1000
    Medical Spa Phone: (573) 446-5166
    Fax: (573) 234-1771